Final words (R.I.P BLOG)

Published April 14, 2013 by ranessaaustin

So long farewell to you my friends good bye for now until we meet again its been great to blog and laugh together on the blog  and now its time to say goodbye…..

(fellas if she ain’t know where i thief ^that from SHE’S TOO YOUNG FOR YOU BRO)

well the blogging is over, the semester is coming to an end , year 1 is almost over. This blogging assignment was definitely one of a kind and props to JM for having such innovative ideas to encourage his students to learn and be interactive. Some people really didn’t like the idea of having to do a blog and was all like i rather do another incourse exam. I really like the idea it combined school work with this generation’s love of social media which is a great thing. My main problem with my blog is my poor time management and love of sleep the same way my Facebook account suffers so did my blog. Maybe if i had an i-phone and i could lie in bed and blog like it was twitter i would have done it more. But overall it was a good assignment as was the entire biochem course i think i can safely say that biochem is my favorite year 1 course and i really did enjoy it.

THANK YOU JM

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Video review #2

Published April 14, 2013 by ranessaaustin

what did I learn??

-respiration is made up of three phases:

glycolsis

krebs cycle

electron transfer chain

– glycolisis is the process by which through chemical reactions glucose is broken down into 2 molecules of pyruvate and produces a net gain of two ATP AND NADH

-pyruvate combines with coenzyme A to form Acetyl-CoA

-krebs cycle is a series of reaction that breaks down the acetyl-coa to form 1ATP, 3 NADH AND 1 FADH, CO2 is produced in this stage of respiration

-In the ETC uses oxygen as the final electron acceptor , to form water.

– 36 ATP are made in the E.T.C

-Fermentation follows gylcolsis when oxygen is not present , there are two types lactic acid (in humans) and alcohol fermentation (in yeast).

– Lactic acid fermentation regenerates the NAD+ which is used to continue gylcolisis to produce the 4ATP which is better than none.

-Alcoholic fermentation is done by yeast cells and produces CO2 and Ethyl alcohol.

The video was quite informative. It held my attention for the entire time the teaching method really reminded me of my own biochem classes it was overall a really good video and i enjoyed it a lot

why such a home wrecker? UCP-1 ,Thermogenin the uncoupler

Published April 13, 2013 by ranessaaustin

                 

 

uncoupling proteins are trans-membrane proteins that decrease the proton gradient generated in oxidative phosphorylation. They do this by increasing the permeability of the inner mitochondrial membrane, allowing protons that have been pumped into the inter-membrane space to return to the mitochondrial matrix.

Brown adipose tissue, exists in mammals, it is possibly the outcome of a single evolutionary development, occurring very early during the evolution of mammals. The mitochondria of this tissue have the protein, uncoupling protein-1 (UCP1, thermogenin),on the inner-membrane. The protein provides an alternative pathway for H+ molecules to return to the matrix from the inter-membrane space. The energy of the H+ is used to generate heat which is used to heat the body for example human babies and mammals that hibernate.

IS THIS THE END OF THE STEM CELL PROBLEM? (published paper #1)

Published April 13, 2013 by ranessaaustin

 New studies have found that cadavers can be the miracle break-through that we have been waiting for. Organs are commonly extracted from cadavers, well now bone marrow extracted from cadavers up to five days old can be used as a source of stem cells that can be used in many lifesaving procedures. Human bone marrow contains mesenchymal stem cells (MSC’s) that can differentiate into cartilage, bone, fat and many other cells. MSC’s cells can be transplanted and develop based on where they are injected, cells injected into the heart can develop into healthy tissue there.

            Stem cell therapies require large amounts of stem cells which can be difficult to obtain from living donors. Acquiring stem cells from cadavers can alleviate this problem as the large quantities are readily available. Acquiring stem cells from cadavers also alleviates the problem of the ethical issues that surrounds fetal stem cell usage. Another plus of using stem cells is the low rejection rate when compared to organ transfers. Unlike other tissue transfers MSC’s taken from one person is not rejected by the immune system of the recipient. This feature make MSC’s invaluable in the treatment of some diseases.

            There are still issues surrounding the use of cadavers.  As Paolo Macchiarini of the Karolinska Institute in Stockholm, Sweden pointed out, the risk associate from using cells from a dead person is still unknown. It is possible that even though the cells in the bone marrow can survive up to five days after death due to the lower oxygen conditions in which they live, their DNA may still have been affected by the dead tissue around them and the dramatic drop in the body’s temperature. Another disadvantage would be that some stem cell procedures require multiple extractions only available from living donors, since all the cells to be used must be collected within the 5day period following death.

            Cadaver stem cells may be a major breakthrough in the stem cell debate providing large amounts of cells and at a low risk rate. But with every new scientific procedure the long term effects of these procedures are yet to be accounted for and can only be found out in time.

http://www.newscientist.com/article/dn23034-cadaver-stem-cells-offer-new-hope-of-life-after-death.html